effect of some organic compounds in the dissolution of calcium oxalate monohydrate crystals

ABSTRACT

Calcium oxalate monohydrate [COM] is considered as the main inorganic crystalline compound of human urinary stones. The mechanisms of its formation and dissolution are not well understood. A number of questions about the promoting and inhibiting factors still remain unanswered. Dissolution rates of COM crystals were studied in absence and presence of aniline [A], ethyl-[2-N-arylamino] acetate [AE] and N-phenyl glycinop hydrazide [AH]. The results showed that dissolution of COM crystals measured at 37°C, I= 0.15 mol.dm[-3] and pH = 6.5 was found to follow surface controlled mechanism [n=2]. The effect of aniline A, Ethyl- [2-arylamino] acetate [AE] and Nphenyl glycimoyl hydrazide [AH] on the dissolution rate of COM was found to follow the sequence A>AE>AH. The flexibility and increase of the basisty are, mainly, responsible factors for this order of inhibition