Prognostic value of protein C concentrations in septic patients in ICU

ABSTRACT

Sepsis is characterized by abnormalities in coagulation, fibrinolysis associated with consumption of protein C, protein C is natural anticogulant vit. K dependant protein which is synthesized in the liver and has anticoagulant anti inflammatory and fibrinolytic properties. The current study was conducted on 20 septic neonates, 10 healthy neonates as control all patients showed low protein C level concentration as compared to controls. Non shocked septic neonates showed significantly higher levels of protein C concentration than neonates with septic shock. Septic shock is associated with increased protein C consumption as indicated by low protein C level in shocked neonates. Low protein C concentration [if detected early] in septic neonates may therefore predict serious complications such as septic shock