Effect of haemodialysis on prolactin level in chronic renal failure

ABSTRACT

Hyperprolactinemia occurs frequently in patients with chronic renal failure and it persists despite dialysis treatment. Hence the study of the actual change in PRL level after a hemodialysis set is essentially reported. Thirty non diabetic male patients with chronic renal failure were selected from Dialysis Units of Port-Said and Ismailia General Hospitals where they underwent chronic hemodialysis [CHD] for all cases the following had been done full medical history, full clinical examination. determination of fasting serum glucose to exclude diabetics as well as serum urea, creatinine, total proteins and PRL before and after a hemodialysis set. The results obtained showed 1. There is a significant hyperprolactinemia among patients on CHD 2. PRL does not significantly change after the set [insignificantly increased]. 3. Some patients have sexual dysfunction and gynecomastia. Finally from our results we conclude that patients undergoing hemodialysis are prone to have clinically significant hyperprolactinemia that may impair their sexual function. Since this complication diminishes the quality of life and limits psychological rehabiltitation, we recommend treatment with bromocriptine [dopamine agonist] to chronic renal failure patients on hemodialysis with sexual dysfunction and exhibit high prolactin