Determination of hydroxyproline in urine of acute and chronic rheumatic heart disease patients

ABSTRACT

The present study was directed towards determination of changes in total urinary hydroxyproline excretion and hydroxyproline/creatinine ratio as important indices for collagen turnover in cases of rheumatic heart disease. The study indicated a significant increase in the total urinary hydroxyproline excretion and hydroxyproline/ creatinine ratios in patients with rheumatic heart disease, than those of control group, there was also a significant increase in both of them in patients with active rheumatic heart disease, than patients with chronic rheumatic heart disease. It has been mentioned that collagen metabolism in patients with rheumatic fever is disturbed, and this disturbance may contribute to the pathogenesis of the disease. Therefore, the measurement of these parameters could be used as an important marker of rheumatic heart disease and rheumatic activity and for the diagnosis and follow up of rheumatic heart disease