Leukocyte antigen [HLA] class ii allele frequencies in female patients with breast cancer: a case control study
BCCR-Basic and Clinical Cancer Research. 2011; 3 (1): 36-44
en Inglés
| IMEMR
| ID: emr-137513
ABSTRACT
The study aimed to examine the association between human leukocyte antigen [HLA] class II allele frequencies and breast cancer in Iranian women. A total of 100 patients with pathologically proven breast cancer who referred to Cancer Institute were randomly selected and compared with a group of age matched healthy blood donors [n = 80]. HLA class II alleles were determined by amplification of DNA followed by HLA-typing using sequence-specific primer [SSP] for each allele. The frequency of HLA-DQA1 0301 [P=0.001, OR=3.4] and HLA-DRB11303 [/M].02, OR=2.3] among breast cancer patients was significantly higher than those in control group. HLA-DQA 10505 [/M].003, OR=0.4], HLA-DRB11301 CP=0.002, OR=0.12] and HLA-DQA10101 [P=0.01, OR=0.21] alleles showed negative association with breast cancer. The findings suggest that HLA-DQA10301 allele is mainly associated with increased risk of breast cancer in Iranian female patients. HLA-DQA 10505 and HLA-DRB11301 alleles are suggested as protective genetic factors against breast cancer. The findings confirm that specific alleles of HLA class II influence breast cancer risk
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Donantes de Tejidos
/
Donantes de Sangre
/
Antígenos de Histocompatibilidad Clase II
/
Estudios de Casos y Controles
/
Factores de Riesgo
/
Alelos
/
Frecuencia de los Genes
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Basic Clin. Cancer Res.
Año:
2011
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