Effect of vasantakusumakar rasa: an ayurvedic antidiabetic drug on central nervous system and gastrointestinal tract

ABSTRACT

The present study was carried out to investigate some pharmacological effects of Vasantakusumakar Rasa [VKR] on the Central Nervous System [CNS] and the Gastrointestinal [GI] Tract utilizing laboratory mice. The CNS study comprised of Hole cross test, Open field test and Hole board test and the GI study comprised of GI-Motility, Castor oil induced and MgSO[4] induced diarrhoeal tests. VKR showed stimulatory effect in the Hole cross test, Open field test and the Hole board head dipping test. In case of GI-Motility test, VKR decreased the gut movement. In case of Castor oil induced diarrhoeal test the mean latent period increased. There was no prominent effect in MgSO[4] induced diarrhoeal tests. Conclusion from the above tests reveals that VKR has CNS stimulant activity and constipatory effect on the Gastrointestinal Tract