association between selected RANKL gene polymorphisms and chronic/aggressive periodontitis in Iranian subjects

ABSTRACT

The primary aim of this study was to investigate the status of RANKL6-7 gene polymorphism in patients with chronic [mild, moderate, severe] and aggressive periodontitis as well as healthy controls. We examined 80 patients for the RANKL6-7 polymorphisms [rs1054016 and rs9567000]. Polymorphism was determined by polymerase chain reaction [PCR] followed by direct sequencing. No statistically significant association was found between the polymorphism in the RANKL 7 gene and periodontal disease [P<0.55]. There was also no polymorphic allele observed in RANKL 6 gene of the study population. We found no association between the studied RANKL polymorphisms and chronic/aggressive periodontitis