prophylactic and therapeutic use of oral sultamicillin [sulbactam/ampicillin] in children with bacterial urinary tract infections

ABSTRACT

Thirty five children suffering from urinary tract infections [U.T.I.] [15 with acute and 20 with chronic recurrent U.T.I.] were included in the study. In vitro sensitivity to the drug showed 100% sensitivity in the acute cases and 75% in the chronic cases. The sensitive cases were treated with oral sultamicillin; a sulbactam-ampicillin combination. Excellent results were reported in fifteen cases with acute U.T.I. with complete disappearance of clinical signs and symptoms together with eradication of the causative organisms. Fifteen cases with chronic recurrent infections were divided into 2 groups. Six cases received the same dosage regimen used in acute U.T.I. After a short time from stopping therapy, superinfection occurred in one case. Nine cases with chronic recurrent U.T.I. were maintained on subtherapeutic therapy for up to 3 months with persistent eradication of causative organisms confirmed by follow up cultures. All patients showed excellent tolerability without appearance of any side effects. The study confirms the efficiency and tolerability of the drug in cases with acute U.T.I. and chronic or recurrent U.T.I. In the latter group, it should be only used if culture results proved its sensitivity. Maintenance with subtherapeutic dose is again recommended for prophylaxis