Preparation and evaluation of [99m]Tc-DMSA lyophilized kit for renal imaging
Pakistan Journal of Pharmaceutical Sciences. 2013; 26 (3): 547-551
en Inglés
| IMEMR
| ID: emr-142615
ABSTRACT
Dimercaptosuccinic acid [DMSA] has been evaluated and used with technetium 99m [[99m]Tc] in imaging of kidneys. DMSA lyophilized kits were prepared and radiolabelled with [99m]Tc. Paper and thin-layer chromatography have been employed using various eluent systems for the radiochemical analysis, percentage labeling and binding capacity of [99m]Tc-DMSA. Female albino rabbits were used for this study. Biological data obtained after intravenous injection of radiolabelled DMSA to female albino rabbits revealed 32.42% uptake and long retention time in the kidneys. On the basis of animal biodistribution data, it is suggested that DMSA when labeled with [99m]Tc is useful complex for renal imaging and can be successfully applied as a diagnostic tool in nuclear medicine. Clinical biodistribution and radiation dosimetry studies are planned in future
Buscar en Google
Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Conejos
/
Radiometría
/
Temperatura
/
Cintigrafía
/
Radiofármacos
/
Ácido Dimercaptosuccínico de Tecnecio Tc 99m
/
Estabilidad de Medicamentos
/
Liofilización
Límite:
Animales
Idioma:
Inglés
Revista:
Pak. J. Pharm. Sci.
Año:
2013
Similares
MEDLINE
...
LILACS
LIS