Serum CA-125 in ectopic pregnancy
IPMJ-Iraqi Postgraduate Medical Journal. 2013; 12 (3): 343-350
en Inglés
| IMEMR
| ID: emr-142896
ABSTRACT
CA-125 is a glycoprotein, its origin is uncertain during pregnancy. It rises during the first trimester and returns to a non-pregnancy range in late pregnancy. To compare CA-125 levels between tubal ectopic and normal intrauterine pregnancy, and to find it's usefulness in differentiating intact from ruptured tubal ectopic pregnancy. This prospective case-control study was carried out on sixty healthy women with single normal intrauterine pregnancy [NIUP] of 6-10 weeks gestation and sixty women with tubal ectopic pregnancy of same gestational age which were further subdivided into twenty-five women with ruptured tubal ectopic pregnancy [REP] and thirty-five women with unruptured tubal ectopic pregnancy [UREP]. The levels of CA-125 were compared between these groups. The mean level of CA-125 in ruptured ectopic pregnancy group was 49.04 +/- 33.63 IU/ml and in unruptured ectopic pregnancy group was 24.3 +/- 16.89 IU/ml. The mean level of CA-125 in normal pregnant women [control group] was 53.95 +/- 31.2 IU/ml. There was a statistically significant difference between mean serum CA-125 levels of ruptured ectopic pregnancy and unruptured ectopic pregnancy group [p< 0.05], also there was a statistically significant difference between mean of CA-125 level of unruptured ectopic pregnancy group and control group [p <0.05], while there was no statistically significant difference between ruptured ectopic pregnancy group and control group [p > 0.05]. CA-125 level is significantly elevated in ruptured tubal ectopic pregnancy than the intact tubal ectopic pregnancy, this increase in CA-125 levels can be used as additional test to identify tubal rupture.
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Rotura Espontánea
/
Antígenos de Carbohidratos Asociados a Tumores
/
Estudios de Casos y Controles
/
Grupos Control
/
Valor Predictivo de las Pruebas
/
Estudios Prospectivos
/
Edad Gestacional
/
Antígeno Ca-125
/
Mujeres Embarazadas
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Iraqi Postgrad. Med. J.
Año:
2013
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