Pharmacokinetic study of mycophenolic acid in Iranian kidney transplant patients
JPC-Journal of Pharmaceutical Care. 2013; 1 (1): 13-18
en Inglés
| IMEMR
| ID: emr-143117
ABSTRACT
The purpose of this study was to characterize the pharmacokinetic parameters of mycophenolic acid [MPA] in Iranian kidney transplant patients. Plasma MPA concentration of mycophenolate mofetile [MMF] 1 gram two times a day was measured in 21 Iranian kidney transplant recipients receiving treatment. Patients who entered the study had been transplanted for more than 3 months and their drug level was supposed to be at steady state. MMF concentration was measured with High- Performance Liquid Chromatography [HPLC]. The plasma MPA concentration-time curve was characterized by an early sharp peak at about 1 hour postdose. The mean Area Under Curve [AUC], Cmax and Tmax were 47.0 +/- 18.3 microg.h/ml, 18.6 +/- 8.5 microg/ml and 1.0 +/- 0.5 hours respectively. The plasma MPA concentration-time curve pattern of Iranian patients was similar and consistent with previously reported profiles in other populations taking the same dose.
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Recolección de Muestras de Sangre
/
Cromatografía Líquida de Alta Presión
/
Trasplante de Riñón
/
Área Bajo la Curva
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
J. Pharm. Care
Año:
2013
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