Detection of rtN236T mutation associated with adefovir dipivoxil resistance in hepatitis B infected patients with YMDD mutations in Tehran
IJM-Iranian Journal of Microbiology. 2013; 25 (1): 76-80
en Inglés
| IMEMR
| ID: emr-143257
ABSTRACT
The risk of adefovir dipivoxil resistance emergence has increased in lamivudine-resistant hepatitis B infected patients. The mutations known as causing adefovir resistance, rtN236T and rtA181V/T, are detected within the D and B functional domain of the HBV polymerase, respectively. In this study, we intended to determine the pre-existing adefovir-resistance mutations in patients infected with LAM resistant mutants prior to starting adefovir therapy. The study included 30 patients with chronic hepatitis B with lamivudine resistance mutations in the YMDD motif that experienced viral breakthrough. After alignment of protein coding sequences, the rtN236T mutation was observed in two [6.6%] patients, while twenty-eight others had neither rtN236T, nor rtA181V/T mutation. All 30 patients were infected with genotype D of hepatitis B virus. The early detection ofLAM-resistance mutations may allow a timely chance of therapy to avoid hepatitis flare- up. This data suggests that monitoring of ADV-resistance mutations in ADV naive patients can be considered in selecting the appropriate anti-viral regimen
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Adenina
/
Virus de la Hepatitis B
/
Lamivudine
/
Farmacorresistencia Viral
/
Organofosfonatos
/
Mutación
Tipo de estudio:
Estudio de tamizaje
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Iran. J. Microbiol.
Año:
2013
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