Prevalence of helicobacter pylori infection in subjects with gastric cancer surgery

ABSTRACT

To determine the prevalence of helicobacter pylori [H. Pylori] infection in patients with gastrectomy for gastric cancer. Samples from 95 [69 males, 26 females] consecutive patients who had undergone surgery for gastric cancer were included in this study. Histologic examination of tumor obtained at the time of surgery yielded the diagnosis and then the specimens were stained with haematoxylin and eosin and Giemsa for the assessment of tumor and H.pylori infection. All patients did H.pylori immunologic and urease test. From 95 patients with gastric cancer, 83 patients [87.36%] were positive for H. pylori infection. Histologic type of tumors was intestinal in 61 patients and diffuses in 7 patients. The prevalence of H. pylori was 93.2% in intestinal type carcinoma and 28.5% in diffuse type [P- value=0.0002]. No significant difference was found in sex, smoking and staging between H.pylori positive gastric cancer and H.pylori negative cases. This study reconfirmed a high prevalence of H. pylori infection in patients suffering from gastric cancer and provided that evaluation for H. pylori infection might confer additional benefit in identifying the population that is at greater risk for this tumor