[Association of uric acid and albuminuria in patients with type 2 diabetes]

ABSTRACT

High serum uric acid is associated with kidney damage manifested by glomerular sclerosis, hypertrophy and albuminuria in animal models. To evaluate the relationship between elevated serum uric acid and urinary albumin/creatinine ratio in type2 diabetes. In this cross-sectional study, 290 patients [130 males and 160 females] with type 2 diabetes were recruited for measuring, cholesterol, triglycerides, uric acid and albumin/creatinine ratio [ACR]. The data obtained for albumin/creatinine ratio were expressed as mean +/- SD or percentage and a P value 0.05 was considered as significant. One-way analysis of variance and Pearson correlation coefficient were used for statistical studies. The mean ages of patients were 58.2 +/- 8.6 years. Uric acid levels for normalbuminuria, microalbuminuria and marcoalbuminuria were [5.1 +/- 0.7, 6.3 +/- 1.1, and 8.1 +/- 1.3 mg/dl, respectively]. While the uric acid level in men was shown to have a positive correlation with natural logarithmic ACR [Ln [ACR]], [Segma=0.53, p<0.05], a positive correlation with both triglycerides and Ln [ACR] was found among women [Segma=0.263, P<0.01]. Based on our data, serum uric acid was found to be independently correlated with urinary ACR in patients with type 2 diabetes