[Association of [Ile462Val in genetic polymorphisms CYP1A1] and uterine leiomyoma risk in women in Charmahal va Bakhtiari, I.R. Iran]

ABSTRACT

Uterine leiomyoma is a benign solid tumor of smooth muscle and the most common type of gynecological tumor. It occurs in approximately 25-30% of women over 30 years old. Studies have shown that the growth of uterine leiomyma was related to estrogen, cousidering the effect of CYP1A1 gene in estrogen metabolism, this study was done to evaluate the association of CYP1A1 [Ile462Val] polymorphisms with uterine leiomyoma in Charmahal va Bakhtiari women. In this case - control study, 156 non menopause women with the age ranges of 17-57, with clinically diagnosed uterine leiomyoma and 151 healthy normal subjects were investigated. The Ile462Val [APCR-RFLP. The data were analyzed by SPSS17 software and using X[2] test. AG genotype was 12/2% P-450 clase A in women with uterine leiomyma, [n=19] and it was 8.6%, in control group [n=13]. No Significant different was found in the frequency of Iie462Val [A>G] Polymorphism between the two groups [P=0.306]. The results of this study demonstrated that the CYP1A1Ile462Val polymorphism was not correlated with an increased risk of uterine leiomyoma in the study population