possible role of gastrin in cholelithiasis in cirrhotics

ABSTRACT

The present study was conducted to find out the relation between gastrin hormone level and the prevalence of gallbladder stones in cirrhotic patients. Eighty five patients with liver cirrhosis and 20 individuals as a control were included in the study. Fasting serum gastrin was estimated and abdominal ultrasonography were done for the patients and the individuals whereas guided liver biopsies were done for the patients. The study showed higher prevalence of gallbladder stones among patients [31.7%], compared to the control [0%]. The study showed a significant increase in serum gastrin level in patients compared with control, moreover, the study showed that serum gastrin levels among patients with gallbladder stones had statistically significant higher levels compared with the serum gastrin among patients having no gallstones. From the present study it can be concluded that gastrin hormone elevation can be a contributing factor for the pathogenesis of gallbladder stones in cirrhotic patients