Xenobiotic metabolising enzymes in DLA induced Balb/c mice and on treatment with protein fractions of Cynodon dactylon and Aegle marmelos

ABSTRACT

The investigation on xenobiotic metabolising enzymes have been carried out in mice liver. In the present study, in vivo studies were carried out using BaIb/c mice. DLA cells were transplanted intraperitoneally and ED[50] dose of protein fractions of Cynodon dactylon and Aegle marmelos were injected intraperitoneally once a day during the course of the study. The levels of xenobiotic metabolizing enzymes phase I [Cytochrome b[5] and P450] and phase II [Glutathione S-Transferase] were found to be increased and decreased in DLA induced mice. Administration of protein fractions significantly reversed the level of enzymes both in the presence and absence of DLA cells. These results indicated the protective role of protein fractions