Study of praziquantel and oxamniquine effects on left ventricular function [an echocardiographic study]

ABSTRACT

In order to evaluate the effects of praziquantel and oxamniquine on left ventricular function, a total of 100 non-cardiac patients with active schistosomiasis were studied. They were classified into Praziquantel group [50 cases] and oxamniquine group [50 cases]. Two-dimensional echocardiography was done for each patient just before the study, four hours and one month after drug intake. Praziquantel has no deletorious effect on left ventricular function in patients without hepatosplenomegaly. While, it has a transient injurious effect on ESV and EF in those having hepatosplenomegaly. Oxamniquine has a reversible deleterious effect on left ventricular function manifested as abnormal ESV and EF in patients with or without hepatosplenomegaly