Enzyme activity changes in the issues of rats with experimental acute uraemia, 1 - the kidney

ABSTRACT

Acute uraemia was induced in Swiss albino rats by bilateral ureteral ligation. The histopathological and histochemical enzymatic changes of uraemic kidneys were studied 48 hours after induction of uraemia. Alkaline phosphatase [Alk. P.] and succinic dehydrogenase [S.D.] enzymes showed diminished activity in the proximal and distal convoluted tubules whereas acid phosphatase [Ac. P.] and alpha-esterases enzymes' activity did not change from normal. These enzyme changes reflect cellular damage in general and disturbance of TCA cycle with consequent disturbance in cellular respiratory functions. This led to the recorded cloudy swelling in the proximal convoluted tubules