Prognostic significance of MRD [minimal residual disease] quantification by PCR in childhood acute leukaemia
Medical Journal of Cairo University [The]. 2007; 75 (2 Supp.): 29-35
en Inglés
| IMEMR
| ID: emr-145636
ABSTRACT
Twenty five cases with acute lymphoblastic leukaemia were included in this study. They received induction, intensification and maintenance chemotherapy [Modified Berlin-Frankfurt-Munster BMP 76/79 Protocol], plus prophylactic cranial irradiation to a total dose of 1800 cGy/ 2 weeks/ 10 fractions. MRD quantification was done using real-time PCR. It was found that patients with negative MRD had much better overall and relapse-free survivals than those with positive one, 100% versus 20% and 100% versus 25% at the end of 24 months follow-up. Again, it was found that PCR-MRD levels > 0.01 or more can predict the relapse and the prognosis of those cases was much worse than those with lower levels
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Pronóstico
/
Niño
/
Enfermedad Aguda
/
Irradiación Craneana
/
Resultado del Tratamiento
/
Neoplasia Residual
/
Hospitales Universitarios
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Med. J. Cairo Univ.
Año:
2007
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