role of Bcl2 and oxidative stress in juvenile diabetes mellitus

ABSTRACT

Diabetes mellitus is on of the most common non-communicable diseases, and if uncontrolled, targets multiorgan systems with serious debilitating and life threatening sequelae. Most diabetic cases fall under the type-2 category, characterized by relatively late onset, development of insulin resistance and for deficiency. Type-I diabetes on the other hand, manifest early during childhood and has an autoimmune component to it, that causes a severe deficiency in the circulating levels of insulin. The study included 32 diabetic child [17 males and 15 females] their age ranged from 3 to 14 years and 20 apparently healthy control of matching age and sex. All patients subjects for the following investigations fasting glucose level, glycated hemoglopin[HBA[1]c],nitric oxide[NO], thiobarbituric acid [TBARS], hydrogen peroxide[H[2]O[2]], total antioxidant [TAO]and Bcl-2. Serum levels of glucose, HBA[1]c, NO[2], H[2]O[2] and TBARS were significantly higher in diabetic patients than in controls while serum levels of TAO and Bcl-2 were significantly lower in diabetic patients than in controls. Also there were positive correlations between serum glucose level with H[2]O[2], TBARS and NO serum levels and negative correlations between serum glucose level with TAO and Bcl-2 serum levels. In conclusion, Bcl-2 [as an anti-apoptotic factor] and oxidative stress state imbalance play an important role in the pathogenesis of diabetes mellitus