Effects of infantile repeated hyperglycemia on behavioral alterations in adult male and female rats
Basic and Clinical Neuroscience. 2012; 3 (4): 60-67
en Inglés
| IMEMR
| ID: emr-146023
ABSTRACT
Anxiety symptoms have been reported to be present in many patients with diabetes mellitus. However, little is known about the effects of hyperglycemia in critical periods of the central nervous system development. We assessed locomotive, exploratory, and anxiety behaviors in adult rats that remained from infantile repeated hyperglycemia by the open field and elevated plus maze tests. Our findings showed significant hypo activity, reduced locomotive/exploratory activities, increased fear related behaviors, and anxiety state between hyperglycemic and control adult males and the same differences were observed among females. In addition, no significant behavioral alterations between male and female animals were observed. This study determined that repeated increments in daily blood sugar levels in newborns may affect neuronal functions and provide behavioral abnormalities in adults
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Recién Nacido
/
Distribución Aleatoria
/
Factores de Riesgo
/
Ratas Wistar
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Aprendizaje por Laberinto
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Conducta Exploratoria
/
Neuronas
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Animales
Idioma:
Inglés
Revista:
Basic Clin. Neurosci.
Año:
2012
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