Rosai-dorfman disease of the larynx. a case report with molecular genetic analysis for immunoglobulin and t-cell receptor genes rearrangement
Mansoura Medical Journal. 2006; 37 (3,4): 97-105
en Inglés
| IMEMR
| ID: emr-150944
ABSTRACT
Sinus histiocytosis with massive lymphadenopathy [SHML], or Rosai-Dorfman disease [RDD], is rare histiocytic disorder originally described in 1969 as a benign Clinicopathoiogic entity characterized by massive bilateral cervical lymphadenopathy and fever. The indolent clinical course of RDD suggests a reactive disorder rather than a neopiastic process. We present a 21 year- old woman with RDD of the larynx with a recurrence of the disease after 13 months. To determine whether the lymphoplasmacytic components in these lesions clonal or polyclonal we performed a molecular testing using PCR and southern blot analyses to examine Immunoglobulin [JH] and T-cell receptor genes [TCR] genes rearrangement. The analysis showed polyclonal pattern [germline] for JH and TCR. Surface marker analysis by flow cytometry and immunohistochernistry revealed a mixed population of T and B cells with no evidence of light or heavy chain restriction. This indicates that the lymphoplasmacytic proliferation in RDD is reactive and consistent with the indolent behavior
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Biopsia
/
Tomografía Computarizada por Rayos X
/
Ronquera
/
Reacción en Cadena de la Polimerasa
/
Estudios de Seguimiento
/
Ultrasonografía
/
Microscopía de Polarización
/
Biología Molecular
Tipo de estudio:
Informe de Casos
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Mansoura Med. J.
Año:
2006
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