[Effect of quercetin on learning and memory in STZ-induced diabetic rat]

ABSTRACT

Diabetes mellitus is common endocrine disease cause learning and memory impairment. This study was done to evaluate the effect of quercetin on learning and memory in STZ-induced diabetic rats was investigated. In this experimental study, 40 male Wistar rats were randomly allocated into five groups control, quercetin - treated control, diabetic and quercetin - treated diabetic [10 and 20 mg/kg/bw, intraperitoneally] for 14 days. Induction of diabetes was performed using 60 mg/kg/bw of streptozotosin, interapritonally. Passive avoidance and Y-maze tests were used for the evaluation of learning and memory. In passive avoidance learning, there was no significant difference in initial latency between diabetic and treated - diabetic groups. The mean of step latency in control group [383.57 +/- 19.26] significantly reduced to 128.86+/-10.38 in diabetic group [P<0.05]. The mean of step latency in the treated diabetic group significantly increased in compare to the diabetic group [P<0.05]. Step latency in quercetin - treated diabetic [10 mg/kg/bw] and [20 mg/kg/bw] groups increased to 316.67 +/- 23.76 and 397.50+/-31.21, respectively. The alternative percentage in diabetic group was significantly lower than control group [P<0.05], but in quercetin -treated diabetic groups it was higher than the diabetic group [P<0.05]. Administration of quercetin for 14 days enhances the capability of the memory storage, recall and improves short-term spatial memory in STZ-induced diabetic rats