Total antioxidant status and lipid parameters among patients of hypothyroidism

ABSTRACT

To determine i] the total antioxidant status in hypothyroid patients and ii] its association with hormonal and lipid parameters. Total antioxidant status [TAS], lipid and thyroid hormone profile was determined in patients [n=27] with Hypothyroidism referred for laboratory assessment of thyroid function in GMCH. Normal volunteers [n=24] served as the control group. Data was analyzed on SPSS 19.0 software. The TAS in normal volunteers was found to be 1.65 +/- 0.32 mmol/L while in patients with subclinical [N=12] and overt Hypothyroidism [N=15] it was found to be 1.25 +/- 0.23 and 1.28 +/- 0.23 mmol/L respectively. While the difference in TAS between the normal and the over hypothyroid group was significant [p<0.001], no significant difference could be observed between the subgroups within the hypothyroid state. TAS was found to be significantly lower in patients with low T3 [<3.1 nmol/L], however no such association was seen with low T4 levels. Serum TSH level was found to correlate strongly and significantly with total cholesterol and LDL levels. TAS was lower in patients with high serum cholesterol levels [p<0.001] but no difference was seen with LDL levels. TAS is significantly lower in patients with both subclinical and overt hypothyroidism compared to normal. TAS levels seem to be associated with low T3 but not T4 levels. While the result appear to show a trend, the sample size is very small and more work is needed. The study is still in progress