[Immunophenotyping in adult acute myeloid leukemia: which prognostic value?]

ABSTRACT

Immunophenotyping is an essential step in the diagnosis of acute myeloid leukemia. Its prognostic value remains controversial with contradictory results. To assess prognostic impact of the immunophenotyping in AML. Our study is retrospective [October, 2005 - July, 2007] concerning 56 cases of AML [AML3 excluded] of the adult from 18 to 55 years old diagnosed and treated in Tunis Aziza Othmana Hospital. The immunophenotyping was performed by flow cytometry [Beckman Coulter EPICS XL MCL [registered sign]. We studied clinical and biological characteristic, immunophenotypic expressions, and parameters of the response to the treatment complete remission [CR], overall survival [OS], relapse free survival [RFS] and relapse in a delay of 1 year and 2 years. SPSS software was used to perform the statistical analysis. The median age of the patients is of 37.7 +/- 11.8 years. Sex-ratio [M/F] is 1.33. Among individual antigenic expressions, only CD7 is associated to lower CR rates [p=0.044]. We did not find any statistically significant association between immunophenotypic expressions and OS nor with relapse or RFS. The impact of immunophenotyping in AML remains controversial because of contradictory results. The research of molecular changes would be an interesting alternative in our context