Physicochemical properties, in vitro release and skin permeation studies of a topical formulation of standardized pomegranate rind extract
Pakistan Journal of Pharmaceutical Sciences. 2015; 28 (1): 29-36
en Inglés
| IMEMR
| ID: emr-153875
ABSTRACT
The aim of the present study was to develop a stable formulation containing standardized pomegranate rind extracts [SPRE] for topical use in the treatment of dermal diseases. Ellagic acid [EA] as the major active constituent of SPRE [not less than 13%] was quantified by HPLC as an indicator for studies on the stability, in vitro drug release, and skin penetration/retention. The formulation prepared with polyethylene glycols [PEG 400 and PEG 4000] containing 5% SPRE has been found to be stable and provide a release rate of 36.6741 +/- 5.0072 micro g/cm2 /h that was best fitted to the zeroorder kinetic model. EA from SPRE did not penetrate the full-thickness rat skin but the skin retention of EA was determined to be 2.22 +/- 0.16 micro g/cm2 with a total recovery of 95.14 +/- 5.51%. The results indicated that this 5% SPRE PEG ointment was of satisfactory physicochemical properties and worth further in vivo investigations
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Piel
/
Administración Tópica
/
Ratas Wistar
/
Ácido Elágico
Límite:
Animales
Idioma:
Inglés
Revista:
Pak. J. Pharm. Sci.
Año:
2015
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