H[2] receptor activity; effect in isolated rabbit heart
Professional Medical Journal-Quarterly [The]. 2014; 21 (5): 933-935
en Inglés
| IMEMR
| ID: emr-153928
ABSTRACT
Histamine can stimulate the heart by directly interacting with cardiac histamine receptors. In the present study we have investigated the H[2] receptor activity in isolated rabbit heart. Cimetidine, a specific H[2] receptor antagonist was used. The isolated heart was mounted in langendroff apparatus. The heart was perfused at a constant pressure with oxygenated Ringer's Locke solution. H[2] receptor antagonist produces negative inotropic effect in the presence of histamine. This indicates that H[2] receptors are present in rabbit heart, and plays a role in mediation of positive inotropic effect produced through CAMP by histamine
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Conejos
/
Histamina
/
Cimetidina
/
Corazón
/
Antagonistas de los Receptores H2 de la Histamina
Límite:
Animales
Idioma:
Inglés
Revista:
Professional Med. J.-Q
Año:
2014
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