Clinical and haematological parameters in adult AML patients: a four year experience at Nanakaly Hospital for blood diseases

ABSTRACT

In adults, acute myeloid leukaemias constitute 80% of all acute leukaemia cases; its incidence progressively increases with age To define the clinical and haematological parameters of adult acute myeloid leukaemia in Erbil City. A painstaking analysis of hospital records of 94 adult patients with acute myeloid leukaemia was undertaken. The cases were diagnosed and managed at Nanakaly hospital during the years 2006-2009. Diagnosis was based on peripheral blood and marrow findings. The myeloid origin was confirmed by cytochemistry, and morphological subtyping was done according to the French-American-British [FAB] criteria. Microsoft excel version 2007 was employed for carrying out statistical analysis. The studied group included 58 males and 36 females [M F = 1.61]. Their ages ranged between 16 and 75 years with a mean age of 33.8 years. Pallor was the commonest presenting feature [70.2%] followed by bleeding [22.3%] then fever [7.5%]. The mean value of Hb was [7.6] g/dl, WBCs [34.5 x10[6]/ L], platelets [39.6 x10[9]/ L]; the percentage of blast cells in peripheral blood was 42.5% and in the bone marrow was 65.9%. AML-M[2] was the most frequent FAB subtype 24.4%. AML was commoner in males than in females [1.61]. AML-M[2] was the commonest FAB subtype. Pallor was the commonest presenting feature. Sudan black-B stain was a useful tool in the diagnosis of myeloid leukaemia