Effects of single-dose praziquantel on morbidity and mortality resulting from intestinal schistosomiasis
EMHJ-Eastern Mediterranean Health Journal. 2000; 6 (5-6): 926-931
en Inglés
| IMEMR
| ID: emr-157868
ABSTRACT
The long-term effect of single-dose praziquantel on morbidity and mortality from Schistosoma mansoni was investigated in surveys in 1987 and 1994 in central Sudan. Prevalence of infection dropped from 53% to 34%, and intensity of infection [400 eggs/g of faeces] from 31% to 18%. There was a reduction in hepatomegaly and hepatosplenomegaly, although splenomegaly alone was unchanged. Prevalence of periportal fibrosis decreased from 14% to 10%. Endoscopic investigation of patients with fibrosis showed a reduction in oesophageal varices from 47% to 30%. Mortality due to bleeding varices was high [community-wide, up to 11/100 infected patients with bleeding]. Thus praziquantel mass treatment can be spaced to a much longer period, reducing the expense of treatment, delivery and distribution
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Praziquantel
/
Esquistosomiasis mansoni
/
Várices Esofágicas y Gástricas
/
Prevalencia
/
Cirrosis Hepática
Tipo de estudio:
Estudio de prevalencia
Límite:
Humanos
Idioma:
Inglés
Revista:
East Mediterr Health J.
Año:
2000
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