Effect of dimethyl diphenyl bicarboxylate on normal and chemically-injured liver
EMHJ-Eastern Mediterranean Health Journal. 2002; 8 (1): 95-104
en Inglés
| IMEMR
| ID: emr-158044
ABSTRACT
This study evaluates the effect of DDB on normal and chemically-injured liver. When given to normal rats DDB had no significant effect on liver enzymes, but in chemically-injured rats there was a significant decrease in the elevated levels of liver enzymes. DDB produced a significant increase in reduced glutathione, glutathione peroxidase and glutathione reductase, and a significant decrease in malondialdehyde and glucose-6-phosphate dehydrogenase in both normal and chemically-injured liver. The histopathology examinations showed a slight improvement with DDB administration. DDB has a beneficial effect on liver enzymes and possesses significant antioxidant properties in normal and chemically-injured liver, and may therefore be clinically useful in treating chronic viral hepatitis B in humans
Buscar en Google
Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Ratas
/
Tetracloruro de Carbono
/
Adyuvantes Inmunológicos
/
Sistema Enzimático del Citocromo P-450
/
Modelos Animales de Enfermedad
/
Glutatión
/
Hepatopatías
/
Pruebas de Función Hepática
/
Malondialdehído
/
Antioxidantes
Límite:
Animales
Idioma:
Inglés
Revista:
East Mediterr Health J.
Año:
2002
Similares
MEDLINE
...
LILACS
LIS