Detection of cotinine in neonate meconium as a marker for nicotine exposure in utero
EMHJ-Eastern Mediterranean Health Journal. 2004; 10 (1-2): 96-105
en Inglés
| IMEMR
| ID: emr-158264
ABSTRACT
Neonate meconium cotinine level was evaluated as a marker of prenatal exposure to nicotine from tobacco smoking by mothers. Mothers admitted to a maternity hospital in Alexandria, Egypt, were divided into 3 groups 10 active smokers, 10 passive smokers and 10 with no tobacco exposure during pregnancy. Urine and saliva samples were collected from mothers and first-day meconium samples from their neonates. Mean maternal urinary cotinine levels, measured using radioimmunoassay, differed significantly between the 3 groups, as did mean salivary cotinine and mean cotinine levels in meconium.There was a significant positive correlation between cotinine levels in meconium and both maternal urinary and salivary cotinine levels. Meconium is an ideal biological marker for testing direct fetal exposure to tobacco smoke in the neonatal period
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Complicaciones del Embarazo
/
Biomarcadores
/
Estudios de Casos y Controles
/
Análisis de Varianza
/
Hipoxia Fetal
/
Fumar Tabaco
/
Intercambio Materno-Fetal
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
East Mediterr Health J.
Año:
2004
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