Hydrazones, thiosemicarbazides, thiosemicarbazones and 1,3-thiazolidin-4-ones derived from acridine synthesis, cytotoxic and antimicrobial activities
Egyptian Journal of Pharmaceutical Sciences. 1990; 31 (1-4): 285-300
en Inglés
| IMEMR
| ID: emr-15968
ABSTRACT
Reaction of 9-hydrazinomethylacridine and 9-acridine carboxaldehyde hydrazone III, IV with aromatic aldehydes or ketones afforded 9- arylidene hydrazinomethylacridines and N2-arylidene-9-acridine- carboxaldehyde hydrazones V, VIII, while reaction of III and IV with alkyl or aryl isothiocyanate afforded 1-[9-acridinomethyl]4-substituted thiosemicarbazides and 1-[acridine carboxaldehyde] 4-substituted thiosemicarbazones VI and IX. The 1,3-thiazolidin-4-one derivatives VII and X have been prepared by cyclocondensation of VI and IX with chloroacetyl chloride. Some of the prepared compounds were evaluated for their in vitro cytotoxic and antimicrobial activities
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Hidrazonas
/
Antibiosis
/
Pruebas de Mutagenicidad
Idioma:
Inglés
Revista:
Egypt. J. Pharm. Sci.
Año:
1990
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