Hydrazones, thiosemicarbazides, thiosemicarbazones and 1,3-thiazolidin-4-ones derived from acridine synthesis, cytotoxic and antimicrobial activities

ABSTRACT

Reaction of 9-hydrazinomethylacridine and 9-acridine carboxaldehyde hydrazone III, IV with aromatic aldehydes or ketones afforded 9- arylidene hydrazinomethylacridines and N2-arylidene-9-acridine- carboxaldehyde hydrazones V, VIII, while reaction of III and IV with alkyl or aryl isothiocyanate afforded 1-[9-acridinomethyl]4-substituted thiosemicarbazides and 1-[acridine carboxaldehyde] 4-substituted thiosemicarbazones VI and IX. The 1,3-thiazolidin-4-one derivatives VII and X have been prepared by cyclocondensation of VI and IX with chloroacetyl chloride. Some of the prepared compounds were evaluated for their in vitro cytotoxic and antimicrobial activities