Synthesis and cardiotonic properties of 6- [3-Pyridyl] nicotinonitrile derivatives

ABSTRACT

A number of 6- [3- pyridyl] nicotinonitrile derivatives were synthesized for their potential cardiotonic activity. This was achieved by reacting ketones [1] with ethyl cyanoacetate to give [II] or [III] depending on the reaction conditions. Similarly cyclocondensation of the same substrates [I] with malononitrile afforded the corresponding derivatives [IV] or [V]