Serum ox-LDL level is reduced with the extent of stenosis in coronary arteries

ABSTRACT

Oxidized LDL [ox-LDL] lipoproteins are proposed as important modified particles triggering pro-inflammatory evertts through receptor-mediated pathways. We evaluated the circulating ox-LDL level on the concept that the chronic immune events may affect ox-LDL clearance as the vessel stenosis develops in coronary arteries. One hundred sixty five subjects underwent coronary angiography and then, subdivided into four subgroups controls [n=85]; SVD, 2VD and 3VD [n=80]. The serum ox-LDL level and other biochemical parameters were measured using ELISA method and routine laboratory techniques, respectively. The serum ox-LDL level in the control group [4.81 +/- 1.41 mU/mg] was significantly higher than patients [4.28 +/- 1.73 mU/mg, P<0.05]. The ox-LDL/LDL ratio was conversely reduced with the extent of stenosis as compared with the controls [P<0.05]. Furthermore, no difference was observed in the ox-LDL/LDL ratio between the 2VD and 3VD patients. We suggested the atherosclerosis process increases the total clearing capacities of the circulating ox-LDL particles