Distribution and protective role of hlab40 in Iranian patients with kawasaki disease; a report from southern Iran

ABSTRACT

Kawasaki disease [KD] clinically presents as a systemic vasculitis syndrome with significant cardiovascular involvement. With different incidence among different ethnic groups, the role of certain human leukocyte antigens and their products has been considered as a crucial predisposing factor in the immune responses in this disease. We determined the distribution of human leukocyte antigens type B for 90 Iranian patients with Kawasaki disease in order to evaluate a possible association between these antigens and this disease in our area. We used the polymerase chain reaction [PCR] sequence specific primers [PCR-SSP] technique for antigen typing. Distribution of these antigens for 89 healthy Iranians used as control. While 7 [3.9%] of our patients were positive for human leukocyte antigen type B 40, there were 18 [10.1%] subjects from the control group who had this antigen with statistically significant difference between patients and control group [CI= 95%, RR=1.15 and P= 0.02]. Data were analyzed by Pearson chi-square test and Fisher's exact test. SPSS version 15 was used for statistical analysis and a P value less than 0.05 considered statistically significant. The presence of higher frequency of allele type-B40 in the control group may represent a protective role for this antigen with resultant decreased susceptibility to KD in our area