Rocuronium bromide: a pharmacological study

ABSTRACT

This work was designed to assess the pharmacological effects of rocuronium. In either isolated preparation or intact animals. Rocuronium [6-96 micro g/ml] caused a significant dose related reduction in the amplitude of rat phrenic nerve diaphragm contraction in response to indirect stimulation, the mean percentage reduction were statistically significant. The addition of neostgmine [0.25 micro g/ml] caused complete reversal of the relaxant effect of rocuronium . In intact cat gastrocnemius sciatic nerve preparation rocuronium [25 - 200 micro g/kg] caused dose dependent statiscally significant reduction. In comparing the drug with succinyl choline by the head drop method the mean time in second was 15.34 +/-1.57 and 10.44 +/-0.91 respectively