Fibronectin, laminin and complement C3 estimation in chronic renal failure before and after hemodialysis: a possible role in the pathogenesis

ABSTRACT

Nineteen patients with chronic renal failure [nine cases with cancer bladder and ten cases with other etiological causes] were studied. Plasma fibronectin, laminin and C3 were checked before and after hemodialysis. The plasma fibronectin, laminin and C3 were significantly reduced in chronic renal failure [CRF] before hemodialysis than in the controls, while fibronectin was significantly reduced in patients with CRF due to cancer bladder after hemodialysis. These changes may be a possible cause of rapid invasiveness of cancer bladder with metastatic formation and repeated infection in patients with CRF. The results were discussed