Simultaneous determination of some pharmaceuticals in hospital effluents Using HPLC with UV and fluorescence detectors
Jordan Journal of Pharmaceutical Sciences. 2012; 5 (1): 21-29
en Inglés
| IMEMR
| ID: emr-163081
ABSTRACT
The development and validation of an HPLC/UV/Fluorescence [FL] detection method is described, which enables the measurement of the most consumed pharmaceuticals [methotrexate, caffeine, diclofenac, glimepiride and ibuprofen] in Jordanian hospital effluents. Separation was done on a RP-C8 column at a flow rate of 1 ml/min using 11 H2O/acetonitrile with 0.1% trifluoroacetic acid. The samples [200 ml each] were extracted and cleaned-up on C18 cartridges. Correlation coefficients of the pharmaceuticals calibration were higher than 0.997 using a UV detector and 0.996 using a fluorescence detector for methotrexate. Recoveries were ranged from 87% to 108.3%
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Rayos Ultravioleta
/
Cafeína
/
Diclofenaco
/
Ibuprofeno
/
Metotrexato
/
Fluorescencia
Idioma:
Inglés
Revista:
Jordan J. Pharm. Sci.
Año:
2012
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