Pre-eclampsia and lipid profile

ABSTRACT

The present study was designed to evaluate the role of lipid profile alteration in the development of Pre-eclampsia. We selected 32 pregnant women, 16 healthy pregnant women [mean age 25.56 +/- 3.68] as normal and 16 already diagnosed preeclamptic women [mean age 24.65 +/- 4.25] as study group. Serum lipid profile [total lipids, cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol] of thirty two women with Pre-eclampsia [n=16], normotensive women [n=16] were monitored. The serum triglyceride concentrations increased significantly [232.18 +/- 106.41 vs. 113.12 +/- 21.3, P<0.01] while Serum HDL-cholesterol concentrations decreased significantly [39.75 +/- 11.99 vs. 51.18 +/- 06.09, P<0.01] in preeclamptic group as compared to normal pregnant women. Lipid metabolism plays a key role in the pathophysiology of Pre-eclampsia. Increased triglycerides levels along with decreased HDL-cholesterol levels and delayed triglycerides clearance and high blood pressure are associated with development of preeclampsia