Peutz -jegher's syndrome: three case reports

ABSTRACT

Peutz-Jegher syndrome [PIS] is an autosomal dominant disease characterized by hamartomatous intestinal polyps associated with muco-cutaneous melanocytic macules. STK11 /LBK1 is proved to be the responsible gene for inheritanatcel[1] Patients with PIS have 15 fold increase risk of developing malignancy[2], which could be gastrointestinal as oesophageal, gastric, pancreatic and colonic or non intestinal cancer such as lung, breast, ovary and testicular cancer. Here we reported three patients presented to the Gastroenterology Department at Ibn Sina Hospital Sudan over the last ten years