Effect of oltipraz therapy on the total collagen content in livers of hamsters infected with schistosoma mansoni

ABSTRACT

Estimation of the total collagen content in livers of hamsters experimentally infected with the Egyptian strain of S. mansoni before and after oltipraz therapy was carried out. The drug was given in a single oral dose of 500 mg/kg body weight. The results obtained revealed that S. mansoni infection caused significant increase in the total collagen content of liver after 60, 70 and 80 days from infection in comparison to normal controls. Administration of oltipraz at an early stage of the disease [7 weeks after infection] led to significant reduction in the total collagen content after 11, 21 and 31 days from therapy in comparison to the respective infected untreated controls. The results obtained were discussed with those of others at the local and the international levels