Wilms tumor: the experience of the anatomic pathology department at king abdul aziz university hospital, Jeddah, Saudi Arabia

ABSTRACT

The aim of this study was to compare clinico-pathological features of Wilms tumor with those reported in literature and explore the possibility of any significant correlations not documented earlier. We retrospectively reviewed 10 cases of Wilms tumor. Surgical material was obtained by nephrectomy specimens that were grossly described and adequately sampled. Diagnosis was made on routine paraffin sections using hematoxylin and eosin stain and examining under light microscope. The tumors were sub -classified according to NWTS classification protocol. WT accounted for 90.9% of pediatric primary renal malignant tumors. All patients were male and the median age was 1.5 years. The most common clinical presentation was abdominal mass in all cases with variable additional features of abdominal pain, weight loss, vomiting hematuria and fever. Histologically. Classic triphasic pattern was found in all cases. The commonly found heterologous structures were skeletal muscles. All the cases revealed favorable histology. The frequently found features were younger age at presentation, abdominal mass and favorable histology which is suggestive of a correlation between the presenting age of less than 2 years, favorable histology and better prognosis