Congenital constriction ring of limbs in subjects with history of maternal substance use
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2015; 25 (5): 383-385
en Inglés
| IMEMR
| ID: emr-166738
ABSTRACT
Congenital Constriction Ring [CCR] is a rare malformation which manifests itself in the form of ring-like constrictive bands. Due to its heterogeneous nature, its etiology remains unclear. Here, we present a series of seven independent individuals afflicted with CCR, which primarily involved the digits. The phenotypic manifestations included terminal phalangeal reduction, anonychia, digit hypoplasia, and acrosyndactyly. Mesoaxial digits in hands and preaxial digits in feet were most frequently affected. Camptodactyly and clubfoot were witnessed in four and one subject, respectively. Curiously, mothers of six of these subjects revealed that they consumed copious amounts of Multani mitti[Fuller's clay] and/or Naswar[nonsmoke-tobacco], during their respective pregnancies. Maternal substance use during pregnancy is not an unusual practice, however, its relationship with CCR as pregnancy outcome remains unexplored. Case-control studies are warranted to elucidate the relationship between the exposure to these substances and the etiology of CCR and/or other limb defects in the offspring
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Estudios de Casos y Controles
/
Trastornos Relacionados con Sustancias
/
Extremidades
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
J. Coll. Physicians Surg. Pak.
Año:
2015
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