Comparison of Ciprofloxacin 0.3% and Moxifloxacin 0.5% eye drops in bacterial corneal ulcers

ABSTRACT

To compare the effect of Ciprofloxacin 0.3% and Moxifloxacin 0.5% eye drops in bacterial corneal ulcers. Prospective randomized trial Ophthalmology department of Pakistan Institute of Medical Sciences, Islamabad. The total duration of the study was 18 months. 100 patients of bacterial corneal ulcers were randomly assigned to two treatment groups A [Ciprofloxacin 0.3%] and B [Moxifloxacin 0.5%] for the treatment of bacterial corneal ulcers. The outcome measures included size of epithelial defect, size of infiltrate and reaction in anterior chamber on day 1, 2 and 3 and week 1, 2 and 3 after the initiation of treatment. They were compared between the two study groups using Student t test and Chi-square test. SPSS version 13 was used for data entry and analysis. The mean age of patients in Group A was 37.6 [+/- 9.7 SD] years and in Group B was 37.4 [+/- 9.2 SD] years. There were 34 [68%] female and 28[56%] male patients in group A and B respectively. There were significant differences in terms of size of infiltrate [p value 0.030] and reaction in anterior chamber [p value 0.002] between the two study groups. A non-significant difference was observed in size of epithelial defect between the two groups [p value 0.158 after 2 weeks]. Our study showed that Moxifloxacin 0.5% is superior to Ciprofloxacin 0.3% eye drops in treating bacterial corneal ulcers in adult patients