Histopathologic changes in liver and kidney of male sprague dawley rats treated with extract of Cardiospermum halicacabum L.
Pakistan Journal of Pharmaceutical Sciences. 2014; 27 (6): 2247-2250
en Inglés
| IMEMR
| ID: emr-166823
ABSTRACT
In traditional medicine Cardiospermum halicacabum L. [Sapindeaceae] is used against various ailments such as rheumatism, nervous diseases, stiffness of the limbs and snakebite. Leaves are crushed and made into a tea, which aids itchy skin. Salted leaves are used as a poultice on swellings. Young leaves can be cooked and used as vegetables. The leaf juice has been used as a treatment for earache as well. In this study we evaluate acute toxicity [10, 50,100 and 500 mg/kg] and pathologic changes in esophagus, stomach, liver and kidney tissues with a magnifying glass and microscope in a row to mark changes to both morphological and histological in comparison to control with the treatment of ethyl acetate extract [dose of 40mg/kg] in male Sprague Dawley rats. The rats were divided into 4 groups consisting of 3 rats per group for acute toxicity and histopathological change. In conclusion, no lethality was observed in acute toxicity study for 7 days. The treatment of ethyl acetate extracts at 40 mg/kg did not show lethal toxicological changes as observed by histopathological examination in the kidney and liver tissues
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Extractos Vegetales
/
Ratas Sprague-Dawley
/
Riñón
/
Hígado
/
Fitoterapia
/
Acetatos
Límite:
Animales
Idioma:
Inglés
Revista:
Pak. J. Pharm. Sci.
Año:
2014
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