[Effects of vitamin and mineral supplements on microalbuminuria and N-acetyl-beta-D- glucosaminidase activity [-betaNAG] in type 2 diabetic patients]

ABSTRACT

The present study was designed to assess the effect of Mg, Zn, vitamin C and E supplements on microalbuminuria and urinary albumin excretion and N-acetyl-beta-D-glucosaminidase activity [betaNAG] in type 2 diabetic patients. In a randomized, double-blind, placebo controlled clinical trial, 69 type 2 diabetic patients were randomly divided into four groups and received one of the following daily supplement for 3 months; group M 200 mg Mg and 30 mg Zn [n=16], group V 200 mg vitamin C and 100 IU vitamin E [n=18], group MV minerals plus vitamins [n=17], group P placebo [n=18]. Serum malondialdehyde concentration as well as urine microalbumin concentration and betaNAG activity and blood pressure were measured at the baseline and following the intervention. Results have revealed that following the intervention urinary albumin decreased in V and MV groups. Urinary betaNAG activity and protein concentration did not change significantly; however, malondialdehyde concentration was significantly decreased in M and MV groups. Finally, systolic, diastolic and mean blood pressure decreased significantly in the MV group. Our findings indicate that a combination of vitamin and mineral could decrease urinary concentration of microalbumin in type 2 diabetic patients. Thus, these supplements could be prescribed to improve renal function in type 2 diabetic patients