Study on the association between squamous cell carcinoma of larynx and HPV by PCR

ABSTRACT

Abroad epidemiologic studies have suggested human papillomavirus [HPV] to be an etiological agent in Squamous cell carcinoma [SCC] of larynx. In this study we investigated the frequency of HPV 16 infection in various neoplastic and non-neoplastic laryngeal tissue. The study was done on 55 cases of laryngeal SCC, 10 cases of dysplastic and 5 cases of normal tissues were analyzed by polymerase chain reaction [PCR] for the presence of HPV 16. none of the five normal and ten dysplastic laryngeal tissues showed the presence of HPV. Seven of fifty-five Squamous cell carcinoma of larynx [12.7%] were positive for HPV type 16. The results suggested that HPV DNA has a major role in squamous cell carcinoma of larynx