Antinociceptive effects of poly herbal oil extract [PHOE]

ABSTRACT

A number of drugs are used widely in the traditional system of medicine or Tibb-e-Unani [Unani medicine] in the management of many diseases but these drug mostly, have not been investigated for their described effects. This study aimed to investigate antinociceptive and anti-inflammatory effects of Herbal Oil [1, 5 and 10 ml/kg] administered orally in mice and rats, using standard behavioral paradigms. It is a poly herbal preparation used in traditional medicine as a remedy for pains and other ailments. The data show that orally administered herbal oil promotes antinociceptive activity against Acetic Acid induced writhing and Formalin induced pain models. The oil also produced a dose dependent inhibition of carrageenin-induced rat paw edema. These effects were significant when compared with saline control group. The results indicate potent antinociceptive component in oil, which justify at least partially the folkloric use of oil in relieving pains