Efficacy of sildenafil citrate [Viagra[TM]] on sexual responses in non-dysfunctional younger-aged men

ABSTRACT

Sildenafil citrate [Viagra [TM]] is a potent inhibitor of the electrolytic enzyme type V phosphodiesterase [PDE5], in the corpus cavernosum and therefore increases the penile response to sexual stimulation. We evaluated the efficacy of sildenafil, in younger men without erectile dysfunction. In this study subjects treated with 25 mg oral dose of sildenafil were found to be associated with higher mean scores for the questions of the International Index of Erectile Function [IIEF]. Frequency of penetration and maintenance of erection after sexual penetration and/or during masturbation were found to be enhanced significantly [p<0.001] in the sildenafil treated men. Similarly mean domain of erectile function, orgasmic function, intercourse satisfaction and over all satisfaction also showed a significantly positive improvement [p<0.001] in the sildenafil group in comparison with their age matched untreated controls. However the sexual-desire domain in sildenafil treated men with respect to their age matched controls showed a non-significant difference. Sildenafil citrate may assist an individual or couple in extending/enhancing the excitement phase or prolonging the sexual interaction and may have other sexual effects not recognized in the clinical studies